Cannabis formulations or Vijaya Leaf Extracts are precisely formulated ayurvedic formulations with therapeutic benefits of a combination of ancient herbs. All the medicines and formulations are backed up by decades of scientific research and knowledge of Vedas. All the medicines are third party tested and approved by the Government of India. The extract is a mixture of many compounds called the Cannabinoids, terpenes and flavonoids. The Cannabinoids are natural compounds found in the plant in the leaves and flowers of the Cannabis plant and are called Phyto cannabinoids. CBD (Cannabidiol) and THC (tetrahydrocannabinol) are the two of the most studied and recognized chemical compounds found within the vast profile of cannabinoids
The Endocannabinoid System (ECS) is present in every human biological system. ECS is a cell signalling system comprised of molecules that act as neurotransmitters (CB1 and CB2 receptors) spread across the human body. This cell signalling system is responsible for mood, inflammation, immunity, pain, stress, sleep and appetite. Phyto-cannabinoids bind with CB1 and CB2 receptors found within ECS. This interaction helps to simulate the cell signalling system and aid regulation of the above-mentioned symptoms. CB1 receptors are found in the brain and central nervous system, lungs, GIT, reproductive organs, vascular system, and muscles. CB2 receptors are mainly in the peripheral organs, especially cells associated with the immune system, skin, bone, and spleen while TRPV1 receptors are found in blood, bone marrow, tongue, kidney, liver, stomach, and ovaries. The phyto-canabinoid CBD has no action on CB1 receptors and very weak action on CB2 receptors. It causes FAAH inhibition (enzyme that degrades THC/CBD) and naturally the body’s 2-AG and/AEA which (are the natural endocannabinoids present in the body) go up (bliss creating molecule, feeling of goodness, well-being), immune system gets regulated, and as well acts on serotonin receptors and mood gets regulated. FAAH degrades AEA &2-AG. THC is partial CB1, CB2 receptors agonist while CBD is TRPV1 agonist. In presence of CBD, THC cannot exert psychoactive effects and any of its toxic effects.
Mechanism of Cannabis in Cancer.
1) B cells are immune cells with the highest levels of CB1&CB2 receptors.
2) Cannabinoids can decrease the production of antibodies.
3) In T cells, cannabinoids clearly regulate T cell proliferation as T cell apoptosis is increased by AEA and CBD, AEA and THC decrease the T cell proliferation.
4) Macrophages – TCH increases macrophage apoptosis.
5) Immunomodulation is mainly regulated by inhibiting immune cell mobilization and increasing apoptosis; endocannabinoids decrease neutrophils and macrophage mobilization to sites of inflammation and dendritic cell migration.
6) CBD can suppress many transcription factors, including NFAT,AP-1 and NF-kB and this accounts for wide spread suppression of many cytokines.
7) THC inhibits interferon- gamma secretion which is also inhibited by CBD.
8) CBD decreases IL-2 production in T-cells and engagement of both CB receptors reduces IL-2 synthesis.
9) THC &CBD decrease the production and release of IL-6.
10) CBD& THC also attenuate the expression of TNF-α-11.
11) Both CB1 &CB2 receptors are expressed in immune cells, including CD-4 and CD-8 leucocytes, B-cells, NK, monocytes, and neutrophils.
12) ∆9-THC supports the modulation of the Th1/Th2 balance by using the control immune action of Th1 and increasing level of Th2.
Thus, primarily cannabinoids cause their immune-suppressive features in Four pathways:
a) Apoptosis induction.
b) Cell proliferation inhibition
c) Cytokine inhibition.
d) Production and induction of chemokine associated with regulatory T-cells.
Therapeutic scope in Cancers:
• Anti-inflammatory
• Chemotherapy induced nausea and vomiting (CINV)
• Tumour regression
• Adjuvant to chemotherapy
• Analgesic- Pain Management
• Insomnia
• Psychiatric
a) Anxiety & Depression
Side Effects:
• Dry mouth
• Dry throat
• Dry eyes
• Euphoria
• Constipation
• Delirium in early high dosing
• Vomiting
These side effects can be prevented by following certain general instructions given upon Consultation
Type of Products:
• Full Spectrum CBD Rich, Balanced, THC Rich
• Broad Spectrum: where THC is less than 0.3%.
• Isolates: CBD Isolate, THC Isolate, whoever no isolates are available in India.
• In India available as Tinctures (Oils), tablets, raw extracts, Rectal Suppositories, and as local application
